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Tesamorelin Tesamorelin (marketed as Egrifta) is an FDA-approved GHRH analog specifically indicated for the reduction of excess abdominal fat

& Sun, S

10.1016/j.anai.2019.04.022 16

Secreted frizzled-related proteins (SFRPs) are antagonists of this pathway that bind Wnts, downregulate their ability to bind and activate FZD receptors, and inhibit this pathway (73)