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Acknowledgments GU thanks Fundao para a Cincia e a Tecnologia (FCT, Portugal) for PhD grant (SFR/BD/146358/2019)

Among the molecular mechanisms proposed, glutamate excitotoxicity, dysregulation of transcription, altered RNA metabolism, defective axonal transport, protein misfolding and aggregation, endoplasmic reticulum stress, disrupted protein trafficking, proteasome impairment, inflammation, activation of cell death signals, mitochondrial dysfunction, and oxidative stress are the most discussed[2, 2932]

Its antioxidant profile makes it an ingredient of interest for dietary supplement formulations

Similar glutathione concentrations have been found in earlier studies in animal tissue or Arabidopsis for mitochondria (Wahllnder et al