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[DOI] [PMC free article] [PubMed] [Google Scholar] Culver G

Puerarin, an isoflavone derived from the root of Pueraria montana var

10.1002/ptr.6848 Phytother Res

AAV-AADC phase-I clinical trials demonstrated safety and a significant improvement of both motor and non-motor symptoms as assessed by the Unified Parkinson Disease Rating Scale (UPDRS), a decrease in OFF-time duration without an increased effect of ON-time dyskinesias, as well as an increase in the uptake of the AADC tracer at PET, which was used as a measure of gene expression (Christine et al