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Rare conditions like autoimmune lymphoproliferative syndrome (ALPS) have been linked to these changes, although overall evidence is limited 9

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

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B6 is especially known for its role in regulating fluid balance and supporting kidney function