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Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)

258 Similarly, elderly individuals exhibit weaker antibody responses upon immunization with influenza and pneumococcal vaccines, underscoring the need for enhanced immunization strategies

Vitamin D deficiency is associated with low mood and depression and increased inflammation in people who have PCOS

(33) analyzed the suprachiasmatic nucleus (SCN) of mice that underwent 1 week of urolithin A (20 mg/kg/day) or vehicle pre-treatment prior to dextran sulfate sodium-induced intestinal inflammation to study the effects of urolithin A on the expression of central clock genes