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doi: 10.1371/journal.pone.0124903 413 LiHZhongCWangQChenWYuanY

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Hydrogen sulfide targets the adenosine triphosphate-sensitive potassium channels, leading to vascular smooth muscle hyperpolarization (paralysis of calcium influx to smooth muscle), resulting in vasodilation and a lack of response to vasoconstrictor stimuli.56 Hydrogen sulfide is produced by cystathionine gamma-lyase found in endothelial cells.56 It affects small arterioles (resistance)