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hence, intratumoral hypoxia is the principal stimulus for HIF activation 2

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While acinar cells of the pancreas express by far the highest levels of ALDH1L2, other cell types show lower levels of expression, including several components of the immune system

This depressing effect of high CO 2 seen here in the short term may also be relevant when plants are grown under high CO 2 conditions, since CO 2 -enrichment is generally detrimental to S content in tissues 11 , including in trees 17