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Ele compara esse fenmeno ao dos esteroides anabolizantes

Specific disulfide linkage between homocysteine and the sulfhydryl group of an intracellular protein may be an alternative molecular mechanism underlying hyperhomocysteinemia-induced vascular dysfunction

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Although the release of these proteins into the cytosol is expected to trigger apoptosis, this form of cell death is negligible in APAP-induced hepatotoxicity, as shown by the absence of caspases activation and the inability of caspase inhibitors to protect against APAP-induced liver injury ( in vitro after treatment with APAP and fructose, which acts as a glycolytic substrate to generate ATP and glycine as a membrane stabilizer (Kon et al., 2004)