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[8] You are experiencing severe or continuous side effects (mentioned above) You continue to feel loss of interest in pleasurable activities or hobbies Your fatigue does not improve Your sleep is disturbed (insomnia, excessive sleeping) You continue to have difficulty concentrating You experience changes in appetite You experience physical aches and pains Because antidepressants alter your brain chemistry, discontinuing them without medical supervision can cause serious symptoms

This includes the ability for stakeholders knowledgeable about particular domains to assess the quality of trials for which information is posted on ClinicalTrials.gov