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Given the decreased exposure to first-pass metabolism, glutathione has superior bioavailability buccally or sublingually as compared to the oral route

My preference is to use it in the day to protect my skin from external environmental aggressions, but you can also use it at night

Szyk P, Czarczynska-Goslinska B, Mlynarczyk DT, lusarska B, Kocki T, Ziegler-Borowska M, Goslinski T (2023) Polymer-based nanoparticles as drug delivery systems for purines of established importance in medicine