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Acute moderate-intensity training increased total immunoglobulin E (IgE) levels in allergic rhinitis patients ( Regular moderate-intensity exercise also increases salivary secretory IgA (SIgA) in older adults ( + B-cell counts and factors related to IgA synthesis, thus strengthening intestinal IgA production and immune function ( 3.1.6 Effects on cytokines Moderate-intensity exercise exerts a wide range of effects on cytokines, especially in the modulation of critical cytokines like IL-6, TNF-, and IL-10.The release of IL-6 from contracting skeletal muscle, first identified as a myokine nearly two decades ago, represents a hallmark cytokine response to endurance exercise

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Inhibition of the EMT by sulforaphane in thyroid cancer cells has been associated with upregulation of an epithelial marker, E-cadherin, and downregulation of a transcription factor (SNAI2), a filament protein (vimentin), and various enzymes (matrix metalloprotein [MMP]-2 and MMP-9) known to contribute to EMT and promote migration (32)