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Description

Lipoic acid synthetase then catalyzes sulfuration at positions 6 and 8 of the octanoyl moiety, forming a dihydrolipoyl moiety (R enantiomer)

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In the final step, lipoyl-CoA is enzymatically transferred from carnitine to intramitochondrial CoA by carnitine palmitoyl transferase II (CPT II) (32)

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Furthermore, an excessive lack of Trp will result in an increase in Kyn synthesis during Trp metabolism, preventing effector T cells and natural killer cells from proliferating and functioning

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Cell Biochem 116 , 27352743 (2015)

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