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StatPearls [Internet] Tins B (2010) Technical aspects of CT imaging of the spine

D.PangP.ZhouX

Designing prodrugs that are inactive in the systemic circulation but are selectively activated by enzymes overexpressed in diseased tissues (e.g., cathepsins and matrix metalloproteinases) allows for the localized release of active copper-modulating agents, thereby minimizing off-target effects [257]