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In lyophilized (freeze-dried) form, removing water slows hydrolytic cleavage of peptide bonds dramatically

In Candida infections, host mitochondria exhibit decreased complex I and complex III activity, correlating with reduced ATP levels and impaired phagocytic killing capacity ( Moreover, gliotoxin from Aspergillus fumigatus and candidalysin from Candida albicans synergistically impair mitochondrial ATP production, weakening epithelial barrier integrity and facilitating fungal invasion ( 4.3 Fungal-induced mitochondrial ROS generation and oxidative stress One of the earliest mitochondrial responses to fungal infection is the excessive generation of mtROS

ROS can disrupt these junctions, resulting in a compromised mucosal immune barrier

Folate-deficiency anemia is also prevalent among patients suffering from inflammatory bowel disease like Crohns disease, likely due to impaired folate absorption (Mullin 2012)