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Wang SW, Gao C, Zheng YM, Yi L, Lu JC, Huang XY, et al

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

indeed, the combination of PLC and the PDE5i sildenafil was found to be more effective than sildenafil as single agent in improving penile erectile function in diabetic patients [25], and the combination of PLC, ALC and sildenafil was more effective than sildenafil as single agent in improving IIEF-15 score and the clinical response to PGE1 injection in patients subjected to radical prostatectomy [26]

Another animal study in 2022 found defective TCR signaling proliferation of segmented filamentous bacteria in the gut of B6SKG mice, driving Th17 cell differentiation and causing autoimmunity in SLE (177)