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Recent studies have demonstrated that NRF2 promotes the survival of not only normal cells but also their malignant counterparts by increasing the expression of several cytoprotective genes (Magesh et al., 2012

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Abbreviations SNO: S -Nitrosylation NO: Nitric oxide PTM: Post-translational modification GO: Gene ontology KEGG: Kyoto Encyclopedia of Genes and Genomes Cys: Cysteine GSNOR: S -Nitrosoglutathione reductase GSNO: S -Nitrosoglyceathione SNP: Sodium nitroprusside GSH: Glutathione Trx: Thioredoxin BST: Biotin switch technique HPDP: N -[6-(Biotinamido)hexyl]-3-(2-pyridyldithio) propionamide IBP: Irreversible biotinylation program CysPAT: Cys-phosphonate labeling OxcyscPILOT: Oxidative Cys selective cPILOT SNO-RAC: SNO-resin-assisted capture TPS: Thiopropyl sepharose SILAC: Stable isotope labeling by amino acids in cell culture TMT: Tandem mass labels SNOSID: SNO Cys site identification nLC-MS/MS: Nanoflow liquid chromatography tandem mass spectrometry ICAT: Isotope coded affinity tag FluoroTRAQ: Fluorescent solid-phase resin with iTRAQ labeling ISA: IodoTMT switch assay DMPO: 5,5-Dimethyl-1-pyrroline n -oxide nESI-MS: Nano spray electrospray ionization mass spectrometry FLIp: FLICE inhibitory proteins Cav-1: Caveolin-1 VEGFD: Vascular endothelial growth factor D PRDX2: Peroxiredoxin-2 HDAC6: Histone deacetylase 6 protein TRAP1: Tumor necrosis factor receptor associated protein 1 FAK1: Focal adhesion kinase-1 DNMT3B: DNA methyltransferase 3B LTBP1: Latent TGF- binding proteins 1 HIF1: Hypoxia-inducible factor 1-alpha ESR2: E2estrogen receptor TOP2A: Topoisomerase II protein VCAM-1: Vascular cell adhesion molecule-1 CaN: Calcineurin phosphatase c-Src: Tyrosine kinase c-Src HB: Hemoglobin GTN: Glyceryl trinitrate AGT: O 6 alkylguanine DNA alkyltransfer SDH: Succinate dehydrogenase PHD2: Prolyl hydroxylase-2 MKP-1: Mitogen activated protein kinase phosphatase-1 TRAIL: TNF related apoptosis inducing ligands PFKM: Phosphofructose kinase AR: Androgen receptor ITG 6: Integrin 6 CSF1R: Colony stimulating factor 1 receptor References Hays E, Bonavida B

S., Khatami, F., Muka, T., & Huicho, L