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To develop the content of this quality care bundle, an Expert Working Group was formed, which performed a systematic review of literature, brainstormed, and debated on key clinical issues before arriving at a consensus strategy that could help physicians achieve this goal

Another potential mechanism of action is vitamin Cs possible impact 2-oxoglutarate-dependent dioxygenases, such as DNA demethylases and histone, which could result in significant epigenetic alterations