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2016 Jan 1 [cited 2025 Apr 19];29(1):3948

At this point, we suggest to better investigate the effect of different dosages by a randomized, double-blind placebo-controlled, longitudinal prospective trial, with three arms (placebo, ALCAR 3 g/day, ALCAR 1.5 g/day) and long-term follow up (12 months)

Broadening the applicability of these restorative procedures and scaling up the industry of cartilage therapies would only serve to further reduce manufacturing costs, and ultimately, the financial burden on both patients and providers

Unlike focal disorders with a single pain generator, CLBP involves overlapping anatomical, biomechanical, and neurogenic components, including discogenic pain, facet joint arthropathy, sacroiliac joint dysfunction, and myofascial sources of pain