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However, a recent study has shown that in order to lethally impact the peroxidation process, PUFAs must be activated and integrated into phospholipids (PLs), a form of membrane lipid, and that free fatty acids cannot trigger ferroptosis

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It has demonstrated a range of anti-oxidative and anti-apoptotic effects in both in vitro and in vivo investigations

In turn, high consumption of n-6 PUFAs has been linked with increased prevalence of allergies in children (259), but this observation was not confirmed by other studies (260262)