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This pattern, corroborated by network analysis, confirms that both components likely contribute significantly to the phenotype of intramuscular fat formation through a complex regulatory network

The same paper is often cited by coffee enema proponents

Ann Clin Biochem 52(Pt 6):705708

Knockout mice lacking wild-type and neuronal NO synthase have much reduced quantities of POMC immunoreactivity in their arcuate nuclei and pituitaries compared to wild-type mice (195,197)