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In addition, according to a systematic review of 35 prospective cohort studies in 14,325 participants age 47 to 101 years followed for an average of 5.4 years, the evidence does not support a role for low vitamin B12 in the development of cognitive impairment or dementia [92]

In orthomolecular medicine, quite dramatic healing effects have been reported as a result of B12 treatments on various forms of nitrosative stress (1)