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Prognosis [edit] An elevation in serum bilirubin level of more than 2 times ULN with associated transaminase rise indicates severe hepatotoxicity and is likely to lead to mortality in 10% to 15% of patients, especially if the offending drug is not stopped (Hy's Law)

Long-term safety beyond 6 weeks remains completely unknown in humans

Mahmoud AM, Hussein OE, Abd El-Twab SM, Hozayen WG (2019) Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPAR, and suppression of NF-B/NLRP3 inflammasome axis

Its Antioxidant and Anti-Inflammatory Effects Every day, your skin faces an onslaught from things like UV rays and pollution, which create unstable molecules called free radicals