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c) Intermediate AVSD is similar to the complete AVSD but has 2 AV valves with a primum ASD and a large inlet VSD

To generate the transgenic lines, we used the skeletal muscle-specific myosin light chain 2 ( mlc2 ) promoter to express the wild-type (WT) human LMNA as well as the five different LMNA mutations, while the heart-specific myosin light chain 7 ( myl7 ) promoter was used to drive the expression of the EGFP transgene as a reporter