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CASE STUDY ANSWER Sixty-seven percent of total standard digoxin clearance is renal, so the standard renal clearance is 0.67 9 L/h = 6 L/h/70 kg with creatinine clearance of 100 mL/min and nonrenal clearance is (1 0.67) 9 L/h = 3 L/h/70 kg (see Table 31 for standard pharmacokinetic parameters)

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Source: PubChem Sequence : YLRIVQCRSVEGSCGF Length : 16 amino acids Disulfide Bridge : Cys7Cys15 Formula : CHNOS Monoisotopic Mass : ~1,813.86 Da (native), ~1,929.92 Da (alkylated) IUPAC Name : Detailed stereochemical descriptor SMILES : Linear chemical chain encoding AOD9604 is studied in experimental models as a tool compound for investigating metabolic signaling and adipose tissue biology