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J Biol Chem 283: 21347-21361 Dowdle J, Ishikawa T, Gatzek S, Rolinski S, Smirnoff N (2007) Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability

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Half-life & zero-order kinetics : Phenytoins metabolism is saturable , resulting in zero-order kinetics (a fixed amount of the drug is cleared regardless of the drug level)

Also, when IGF-I was used to monitor total parenteral nutrition therapy in catabolic patients, the changes correlate with improvements in protein metabolism[373]