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534 Downregulation of GPX4 may result in the accumulation of lipid peroxides and the induction of ferroptosis, thereby promoting atherosclerosis

Iron toxicity results when the amount of circulating iron exceeds the amount of transferrin available to bind it, but the body is able to vigorously regulate its iron uptake

bioRxiv 10.1101/2020.02.20.958579

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication