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In turn, GATOR1 acts downstream of a protein complex named GATOR2, that is composed of MIOS (meiosis regulator for oocyte development), WDR24 (WD repeat domain 24), WDR59 (WD repeat domain59), SEH1L (Seh1-like nucleoporin), and SEC13 (Sec13 homolog nuclear pore and COPII coat complex component) and is required for mTORC1 activity