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Hepatic insulin resistance is associated with hyperinsulinemia from increased insulin secretion and decreased insulin clearance (3,15)

To investigate how conditions in the aged spleen impact T cell functions, naive CD4 + T cells (CD4 + CD25 CD62L + CD44 lo ) were purified from the spleens and LNs of aged mice and activated ex vivo using plate-bound anti-CD3 and anti-CD28