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Agents such as sorafenib, sulfasalazine, and artesunate have shown efficacy in promoting ferroptotic death in tumor models, particularly in those resistant to apoptosis-based treatments ( Emerging evidence also suggests that ferroptosis is tightly coupled to lipid metabolism, membrane repair systems, and oxidative signaling

Voloboueva LA, Emery JF, Sun X et al (2013) Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

Future clinical trials should consider using updated primary endpoints that do not take years to develop such as such as nerve conduction deficits and a combination of drugs/compounds that are safe for human use combined with proper lifestyle modifications in diet and exercise (132)

However, the results barely achieved statistical significance