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This is followed by the activation of the STAT3 pathway and the induction of M2 polarization, accompanied by upregulation of IL-10 (117)

Domazetovic et al

In melanoma, ROS is also capable of ectopic peroxisome proliferator activated receptor- from the nucleus into the cytoplasm via mitogen-activated protein kinase kinase 1, thereby inducing an increase in TNF-, which not only plays an antitumor role, but also converts TAMs into a phenotype that promotes tumor invasion (112)

---------- In Combination with Bortezomib and Dexamethasone (XVd) The recommended dosage of XPOVIO is 100 mg taken orally once weekly on Day 1 of each week until disease progression or unacceptable toxicity in combination with: Refer to Clinical Studies (14 -N'-(pyrazin-2-yl)prop-2-enehydrazide