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In the SMILES trial, only participants with major depressive episodes were included, and they found significant improvement in depression and noted 32.3% of their sample achieved remission after 12 weeks on the diet (122)

Anyway, since these drugs have binding affinities for 5-HT 2A in the nanomolar range, concentrations of 100 M are well above in vivo or clinically relevant levels, risking the activation of off-target receptors (for instance, 100 M NBOH is approximately 450,000 times its binding affinity to 5-HT 2A ) (Poulie et al., 2020)

Kojima H, Kunimoto H, Inoue T, Nakajima K

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