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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, et al

Repressive histone marks (H3K27me3 via EZH2) accumulate on follicle-activating loci, whereas loss of acetylation by over-active HDACs curtails transcription of antioxidants and hormone-synthesis enzymes [119, 120]

It is now well recognized that mitochondrial dysfunction plays a crucial role in the downstream signaling pathways following APAP overdose (Ramachandran and Jaeschke, 2018)