glutathione to glutamine 5 Route of synthesis of (GSH) involving three amino acids Major metabolic and biosynthetic fates

Acute respiratory distress syndrome: role of oleic acid-triggered lung injury and inflammation

These healthspan improvement findings have profound implications for longevity research, development of geroprotective therapies, and understanding how senescent cell accumulation contributes to the functional decline characteristic of biological aging

For example, Oh et al

Key molecular features of ferroptotic cells include abnormal iron accumulation and dysfunction of glutathione peroxidase 4 (GPX4), thereby highlighting the complex interplay of this process with cellular pathways regulating iron homeostasis, lipid metabolism, and amino acid processing ( Figure 3 )