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Nat Methods 5 , 553559 (2008)

Hughes-Austin, Jan M et al

Nanomedicine 14, 787798

Deferoxamine (DFO) is an iron chelating drug that targets free pro-oxidized iron, blocking and attenuating iron-dependent ROS production and iron death, and it significantly attenuated CI/RI injury in animal models in preclinical studies (Van Der Loo et al., 2020), and in recent years, a combination of intravenous recombinant tissue-type plasminogen activator (tPA) has been shown to be effective against stroke patients efficacy of a multicenter, randomized, double-blind, placebo-controlled, dose-discovery phase II clinical trial validated the favorable safety profile of this targeted drug (Milln et al., 2021)