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SKU: 15844530100
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Description

94 WangC

Despite advances made in the understanding of FRDA pathophysiology, the role of iron in this disease has not yet been completely clarified

Under neuropathological conditions, impaired activity of peroxisome proliferator-activated receptor (PPAR) can inhibit lactoferrin (Ltf) transcription, leading to increased free iron concentrations and increased lipid peroxidation levels in neurons, thereby exacerbating ferroptosis