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TB-500 and Neurological Recovery Research In a rat embolic stroke model, administration of T4 at 24 hours after middle cerebral artery occlusion and every 3 days for 4 additional doses produced significant improvement in functional neurological outcome with evidence of axonal remodelling at the ischaemic boundary, increased oligodendrocyte precursor cells in the SVZ, striatum, and corpus callosum, and increased mature oligodendrocytes suggesting a mechanism involving axonal remodelling rather than direct neuroprotection

During the study, female mice were given metformin alone at 500 mg per kg, melatonin at 1mg per kg, or a combination of melatonin at 2mg per kg with testosterone

Under hypoxic conditions, proline hydroxylase cannot negatively regulate the stability and ubiquitination degradation of HIF-1 through oxygen-dependent hydroxylation modification, resulting in HIF-1 accumulation and translocation to the nucleus and binding to HIF-1 to form a complex, followed by the recruitment of coactivators (CBP/P300) at the hypoxia response element (HRE) to upregulate the transcription of glucose transporters and glycolytic enzymes to promote anaerobic glycolysis [84, 85]

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