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CXCL10 might be a universal key factor that damages ovaries under diverse NRTPs To examine whether CXCL10 is still the key damaging factor on ovaries for the invasion of other NRTPs, we used another two cancer cell lines that are not related to female reproductive tissues: MC38, a mouse colon cancer cell line, and B16F10, a mouse melanoma cell line

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8 Ex vivo studies further confirmed GAPs efficacy in reducing oxidative deoxyribonucleic acid (DNA) lesions and cyclobutene pyrimidine dimers under UVA and UVB irradiation, respectively, though these findings were limited by the small number of biomarkers evaluated

The induction of MPT triggers release of intermembrane proteins such as apoptosis inducing factor (AIF) and endonuclease G into the cytosol and their translocation to the nucleus, causing nuclear DNA fragmentation and activation of regulated necrosis