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Second, translational tools should focus on dual-targeted nanocarriers designed to reach cerebellum and myocardiumusing TAT peptides for bloodbrain barrier penetration and CTP peptides for cardiomyocyte targetingloaded with mitochondria-directed ferroptosis modulators capable of activating GPX4 while supporting ironsulfur cluster synthesis, and released in response to GAA-repeat-dependent triggers to avoid off-target iron perturbation

da Silva Toscano GA, de Arajo II, de Souza TA, Mirabal IR, de Vasconcelos Torres G

Pregnant or breastfeeding individuals should also seek medical guidance before supplementation