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IMPORTANT ENZYMES THAT MEDIATE PHASE II DRUG BIOTRANSFORMATION IN MAN UGTs Drug Glucuronidation by UGT Enzymes UGT enzymes (EC 2.4.1.17) catalyze the glucuronidation of polar aglycones that contain phenolic, alcoholic, or carboxylic oxygen atoms and a limited number of nitrogen- and sulfur-containing molecules