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KEGG enrichment of differential metabolites As presented in Figure 7 , the KEGG metabolic pathway enrichment analysis demonstrated that significantly differential metabolites between the MCE and CON groups were enriched in Nucleotide metabolism, Lipid metabolism, Metabolism of cofactors and vitamins, Metabolism of other amino acids, Carbohydrate metabolism, Amino acid metabolism and others

Vitamin D deficiency has been shown to cause over-activation of the dual RAS system of which ACE2 is an important regulator [118]

The outcome of this retrograde signaling from the chloroplast to the nucleus is a change in gene expression in favor of photoacclimation