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Over time, a condition called pernicious anemia, leading to unhealthy red blood cells, might develop

The endocrine and metabolic adaptation observed in both models may be a strategy to increase life span through a slower cell growing/metabolism, a slower loss of physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells

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Moreover, the uncertainties can then be used to understand the probability of what may appear to be outliers due to the properties of the normal distribution.