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Given the lipid-rich composition of myelin, such metabolic perturbations precipitate myelin deterioration and demyelination, leading to a decrease in nerve conduction velocity (Johnson and Stolzing, 2019

As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer