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Mitochondria serve a key role in ferroptosis by acting as central regulators of cellular redox balance, iron metabolism, lipid peroxidation and ROS production

Samples were then alkylated with 60 M IAM-TPP or IAM for 20 min at RT in the dark and then reduced with 120 M TCEP for 3 min and additionally alkylated with 240 M IAM or IAM-TPP for 20 min at RT in the dark

The LKB1AMPK pathway acts as a cell metabolic checkpoint, arresting cell growth under low intracellular ATP conditions, such as in nutrient-deficient states [301]

Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association