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With the problems showing the urgent need for transformation, FDA Director General Paolo Teston has established a strategic roadmap designed to turn the agency into a more responsive and future-ready institution. Developed with the FDA management committee, the plan marks a unified commitment from leaders to sustain and build upon ongoing reforms, accelerating progress, the agency said

Malhotra A et al., SURMOUNT-OSA, NEJM 2024 (NEJMoa2404881, PMID 38912654) : tirzepatide and obstructive sleep apnea, AHI -25,3 to 52 weeks

10.1016/j.jams.2012.05.003 314 YoonS.-Y.YeoJ.-H.HanS.-D.BongD.-J.OhB.RohD.-H

If you are experiencing significant fatigue , persistent nausea, or other side effects that have not resolved before your scheduled increase, staying at your current dose for an additional two to four weeks is both safe and sensible