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The optimal duration of enclomiphene therapy before a drug holiday or transition to another approach has not been formally studied

Novo Nordisk leadership maintained that a 23% weight loss result was clinically significant in its own right

This combination is frequently used in research models to examine both localized and systemic signaling mechanisms and how they may interact within complex biological systems

Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)