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The systemic vasodilation instigated by sepsis further decreases systemic vascular resistance and cardiac output 15 , thereby accentuating the intertwined connection between sepsis and cardiac dysfunction, necessitating the development of efficacious therapeutic strategies

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PGI-C response of moderately improved or much improved. This group of patients, often refractory to treatment, had higher response rates with ritlecitinib than with placebo, although rates were lower than in patients without AT or AU.8 Patients with abnormal eyebrow or eyelash scores Among patients without normal eyebrow or eyelash assessment scores at baseline, improvement by 2 grades in eyebrow score or normalization of eyelash score increased over time across all four ritlecitinib groups (Fig