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Consistent with CIPN being a direct consequence of the pharmacological effects of the taxanes on sensory neurons, higher single as well as higher cumulative doses are associated with both a greater risk for development of this side effects, as well as increased severity of symptoms (Pace et al., 2007

Therefore, the fate of glucose 6-phosphate is influenced by the cells current demand for NADPH

From the accumulated data it appears that dietary lipids will affect GM of fish and will select for several groups of bacteria producing compounds like SCFAs that will affect gut-brain and GM signaling

Since glutamine is an amino acid that is naturally produced in the body and found in many foods, there is no concern that its harmful in normal quantities