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10.3390/ijms241411294 64 JiaoF.TangW.HuangH.ZhangZ.LiuD.ZhangH.et al (2018)

N.JilaniS

The mechanism by which NRF2 inhibits the NF-B signaling pathway can be divided into the following parts

Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants