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Recent work indicates that ATII cells play a pivotal role in the comorbid pathogenesis of IPF and lung cancer-associated fibrosis ( The NLRP3 inflammasome, a critical intracellular multiprotein complex of innate immunity, can be activated by danger signals such as silica (SiO 2 )

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The use of CEUS in abdominal sarcoidosis has been evaluated in small case series or case reports [45], due to the scarcity of the cases and also to the fact that patients with hepatosplenic sarcoidosis rarely present with focal lesions, making them difficult candidates for CEUS (Figure 3)