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& Blomberg, B

After 3 d, TGR dsRNA-treated parasites had darker bodies with internal vacuoles and did not move, while all irrelevant dsRNA-treated parasites showed contractile movement and had clear bodies (Figures 8 and Figure S2)

Another mechanism by which succinate can activate HIF1 is through its oxidation, coupled with an increased mitochondrial potential membrane, which increases ROS production and thus the stability of HIF1 (113)